Peak tissue levels in rats occur within 1 hr. The oral LD50 in rats for a formulation containing 0.3% Lauramine Oxide was estimated to be >20 g/kg.
The international Organisation for Economoic Co-operation and Development reported that amine oxides are not reproductive or developmental toxicants. Study no. EWG is in the process of updating this score. The email address and/or password entered does not match our records, please check and try again. Third Conf. *, Hecht SS , Morrison JB , Wenninger JA . if any. *, Springborn Life Sciences, Inc. (1987) Submission of unpublished data by CTFA.
Contact us if you experience any difficulty logging in. N,N-dimethyl-4-aminobutyric acid and its N-oxide accounted for 28, 28 and 23% in man, rats and rabbits, respectively.
Modification in voluntary filing of cosmetic product ingredient and cosmetic raw material composition statements, N-nitroso-N-methyldodecylamine and N-nittoso-N-methyltetradecylamine in hair-care products, Studies of in vitro cell transformation and mutagenicity by surfactants and other compounds, The carcinogenic effect of nitrosomethyldodecylamine in European hamsters, Induction of urinary bladder tumors in rats by administration of nitrosomethyldodecylamine, Induction of carcinogenesis in Fischer rats by methyl- alkylnitrosamines, Carcinogenesis by exposure to nitrites and amines, Induction of tumors in rats by feeding nitrosatable amines together with sodium nitrite, Utility of amine oxides in oil/water cosmetic systems, The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine, Dermatitis from Ammonyx LO, a constituent of a surgical scrub, The acute toxicity of three oil dispersants, The absorption, tissue distribution, and excretion of dodecyldimethylamine oxide (DDAO) in selected animal species and the absorption and excretion of DDAO in man, Toxicity and carcinogenicity of N-nitroso-compounds, Comparing dodecylmethylamine oxide with stearyldi-methylamine oxide, Oil spill clean-up: the effect of three dispersants on three subtropical/ tropical seagrasses, A comparison of the elimination and biotransformation of dodecyldi- methylamine oxide (DDAO) by rats, rabbits, and man, Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide, https://doi.org/10.3109/10915819409141001, Amended Final Report of the Safety Assessment of Cocamidopropylamine Oxide1. (, Cosmetic, Toiletry, and Fragrance Association (CTFA).
Journal of the American College of Toxicology, Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine, Methods for detecting carcinogens and mutagens with the Sa/monella/mammalian-microsome mutagenicity test, The relationship between mutagenicity and carcinogenicity of some nitrosamines, Mutagenicity of amine drugs and their products of nitrosation, Comparison of the carcinogenic effects of five nitrosamines in guinea pigs, Amine nitrosation and nitrosation by gaseous nitrogen dioxide, International Agency for Research on Cancer, Amine oxides.
Several pathways exist for metabolism of lauramine oxide: omega,beta-oxidation of alkyl chains (the most common pathway for surfactant metabolism), hydroxylation of alkyl chains, and reduction of the amine oxide group. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article?